Validation of a coupled electromagnetic and thermal model for estimating temperatures during magnetic nanoparticle hyperthermia

نویسندگان

چکیده

Purpose Alternating magnetic field (AMF) tissue interaction models are generally not validated. Our aim was to develop and validate a coupled electromagnetic thermal model for estimating temperatures in large organs during nanoparticle hyperthermia (MNH).Materials methods Coupled finite element validation performed by comparing the results experimental data obtained from measured homogeneous agar gel phantoms exposed an AMF at fixed frequency (155 ± 10 kHz). The validated applied three-dimensional (3D) rabbit liver built computed tomography (CT) images investigate contribution of heating nonspecific eddy current as function amplitude.Results Computed were excellent agreement with calculated using analytical method (error < 1%) (maximum absolute error <2% each probe location). 3D concentration 5 mg Fe/cm3 tumor revealed maximum temperature ?44 °C ?40 amplitude ?12 kA/m (peak).Conclusion A developed estimate due phantoms. successfully used analyze distribution complex geometry MNH. In future, should be extended heterogeneous phantoms, include heat sink effects major blood vessels.

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ژورنال

عنوان ژورنال: International Journal of Hyperthermia

سال: 2021

ISSN: ['1464-5157', '0265-6736']

DOI: https://doi.org/10.1080/02656736.2021.1913244